ACADEMIC PUBLICATIONS

I’ve been fortunate to have worked on several different research projects in an array of interesting fields

Keep an eye on the space below to see the list of publications my work has contributed to (hopefully!) grow...

Two alternative methods for the retrieval of somatic cell populations from the mouse ovary

We present two methods for the isolation of somatic cells in the ovary. These methods are suitable for a range of applications relating to the study of folliculogenesis and mouse ovarian development. 

Establishing and maintaining fertility: the importance of cell cycle arrest
(Review)

Our review focuses on the Cip/Kip family of cyclin-dependent kinase inhibitors (CKIs) in mouse gonad development. We particularly highlight recent single-cell RNA sequencing studies that show the heterogeneity of cyclin-dependent kinase inhibitors. 

Primary sex determination in birds depends on DMRT1 dosage, but gonadal sex does not determine adult secondary sex characteristics

We show that DMRT1 dosage is the key sex determination factor in birds and is essential for testis development. Furthermore, we provide additional evidence that birds, in contrast to mammals, have acquired cell-autonomous sex identity (CASI) and that the sex hormone environment does not significantly influence avian secondary sexual characteristics. 

Tissue-Specific In Vivo Biotin Chromatin Immunoprecipitation with Sequencing in Zebrafish and Chicken

We describe a tissue-specific biotin ChIP-seq protocol for zebrafish and chicken embryos. We utilise AVI tagging of Transcription Factors, permitting their biotinylation by a co-expressed nuclear biotin ligase, to achieve tissue-specificity.

Genome and epigenome engineering CRISPR toolkit for in vivomodulation of cis-regulatory interactions and gene expression in the chicken embryo

The novel genome and epigenome engineering toolkit developed here enables manipulation of endogenous gene expression and enhancer activity in chicken embryos, facilitating high-resolution analysis of gene regulatory interactions in vivo.

OTHER PUBLICATIONS

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Report for the WHO Expert Advisory Committee on Developing Global Standards for Governance and Oversight of Human Genome Editing: Current capabilities for human genome editing

April 2021

In depth report on current genome editing technologies and their possible uses in human genome editing.

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CRISPR Journal: 
Going Public With Your Research

November 2020

A short feature article on public engagement around genome editing technologies

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IAI: 
IS GENE EDITING THE WAY FORWARD?

January 2020

A short feature article on genome editing

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NESTA Tipping Point Prize: 
GREEN EDITING: The environmental benefits of

gene-tweaking 

May 2019

Finalist essay on the environmental benefits of genome editing.

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THE BIOCHEMIST: 
REWRITING THE BOOK OF LIFE

Junes 2016

A short feature article on genome editing